Category: 4. Health

  • Adaptive defenses against malicious jumping genes

    Adaptive defenses against malicious jumping genes

    Adverse genetic mutations can cause harm and are due to various circumstances. “Jumping genes” are one cause of mutations, but cells try and combat them with a specialized RNA called piRNA. For the first time, researchers from the University of Tokyo and their collaborators have identified how the sites responsible for piRNA production evolve effective behaviors against jumping genes. This research could lead to downstream diagnostic or therapeutic applications.

    The word mutation can mean…

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    News Source: www.sciencedaily.com

  • Scientists use cellular programming to mimic first days of embryonic development

    Scientists use cellular programming to mimic first days of embryonic development

    The earliest days after fertilization, once a sperm cell meets an egg, are shrouded in scientific mystery.

    The process of how a humble single cell becomes an organism fascinates scientists across disciplines. For some animals, the entire process of cellular multiplication, generation of specialized cells, and their organization into an ordered multicellular embryo takes place in the protective environment of the uterus, making direct observation and studies challenging. This makes it…

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    News Source: www.sciencedaily.com

  • Breakthrough molecular movie reveals DNA’s unzipping mechanism with implications for viral and cancer treatments

    Breakthrough molecular movie reveals DNA’s unzipping mechanism with implications for viral and cancer treatments

    Scientists at the University of Leicester have captured the first detailed “molecular movie” showing DNA being unzipped at the atomic level — revealing how cells begin the crucial process of copying their genetic material.

    The groundbreaking discovery, published in the journal Nature, could have far-reaching implications, helping us to understand how certain viruses and cancers replicate.

    Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase…

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    News Source: www.sciencedaily.com

  • New function discovered for protein important in leukemia

    New function discovered for protein important in leukemia

    Researchers from Northwestern University have stumbled upon a previously unobserved function of a protein found in the cell nuclei of all flora and fauna. In addition to exporting materials out of the nucleus, the protein, called Exportin-1 (also called Xpo1 or Crm1), seems to play a role in promoting gene transcription, the process that creates RNA replicas of strands of DNA to express genes.

    Transcription factors, which regulate transcription, can also direct genes to interact with the…

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    News Source: www.sciencedaily.com

  • Beating the clock: Melanoma starts evading treatment within hours — here’s how to stop it

    Beating the clock: Melanoma starts evading treatment within hours — here’s how to stop it

    Researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes.

    The study, published in Cell Systems and conducted by researchers at the Institute for Systems Biology (ISB) and Massachusetts Institute of Technology (MIT) identifies a non-genetic, reversible adaptation mechanism that allows melanoma cells to survive treatment with BRAF inhibitors. By identifying and blocking this early…

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    News Source: www.sciencedaily.com

  • The cell’s powerhouses: Molecular machines enable efficient energy production

    The cell’s powerhouses: Molecular machines enable efficient energy production

    Mitochondria are the powerhouses in our cells, producing the energy for all vital processes. Using cryo-electron tomography, researchers at the University of Basel, Switzerland, have now gained insight into the architecture of mitochondria at unprecedented resolution. They discovered that the proteins responsible for energy generation assemble into large “supercomplexes,” which play a crucial role in providing the cell’s energy.

    Most living organisms on our planet-whether plants, animals, or…

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    News Source: www.sciencedaily.com

  • Pediatric Brain Tumor Classification Improves Therapy

    Pediatric Brain Tumor Classification Improves Therapy

    Cancer is the rapid proliferation of malignant cells that permeate tissue and cause dysregulation of the body’s daily functions. Many cancers can be characterized by the mutation cells have and how the tumors behave. Specifically, tumors are graded based on location and aggressive nature, which informs physicians of tumor resistance to therapy. Unfortunately, there are various tumor types and each one can respond differently in a patient. Many…

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    News Source: www.labroots.com

  • Immune Cell Mechanism Improves Antibody Production

    Immune Cell Mechanism Improves Antibody Production

    Our immune system works to fight infections immediately, but also maintain long-term immunity. Two waves of protection help neutralize and eliminate disease, including the innate and adaptive immune responses. Innate immunity comprises of non-specific immune cells that recognize an invading pathogen and activate a broad response. This first wave of protection is responsible for initial inflammation and notifying the rest of the body of infection. The…

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    News Source: www.labroots.com

  • Trials Indicate Vagus Nerve Stimulation may Relieve Depression

    Trials Indicate Vagus Nerve Stimulation may Relieve Depression

    In clinical trials, almost 500 depression patients who were resistant to current treatments were given therapy that stimulated their vagus nerve. The majority of these patients had such serious depression that they were unable to work. The study showed that after one year, depression symptoms, quality of life, and the ability to do everyday tasks improved in the treated individuals. The findings have been reported in two studies in the journal Brain…

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    News Source: www.labroots.com

  • 5 years on, true counts of COVID-19 deaths remain elusive − and research is hobbled by lack of data

    5 years on, true counts of COVID-19 deaths remain elusive − and research is hobbled by lack of data

    In the early days of the COVID-19 pandemic, researchers struggled to grasp the rate of the virus’s spread and the number of related deaths. While hospitals tracked cases and deaths within their walls, the broader picture of mortality across communities remained frustratingly incomplete.

    Policymakers and researchers quickly discovered a troubling pattern: Many deaths linked to the virus were never officially counted. A study analyzing data from over 3,000 U.S. counties between March…

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    News Source: theconversation.com