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Evaluating the safety and efficacy of a smallpox vaccine for preventing mpox

The recent global monkeypox (mpox) outbreak, with a new and aggressive variant, has underscored the dire need for safe, broadly effective, and accessible vaccines. The LC16m8 vaccine, an attenuated vaccinia virus strain originally developed for smallpox, is a promising option for countering the mpox virus. Exploring this potential further, researchers employed a cross-species immunological analysis to provide new insights into LC16m8’s immunogenicity and safety against mpox.

In recent years,…

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News Source: www.sciencedaily.com

May 8, 2025
Building vaccines for future versions of a virus

Effective vaccines dramatically changed the course of the COVID-19 pandemic, preventing illness, reducing disease severity, and saving millions of lives.

However, five years later, SARS-CoV-2 is still circulating, and in the process, evolving into new variants that require updated vaccines to protect against them.

But it takes time to design, manufacture, and distribute a new vaccine, which raises an important question: How can scientists create vaccines for versions of the virus that…

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News Source: www.sciencedaily.com

May 8, 2025
Vitamin supplements slow down the progression of glaucoma

A vitamin supplement that improves metabolism in the eye appears to slow down damage to the optic nerve in glaucoma. Promising results have been published in the journal Cell Reports Medicine. The researchers behind the study have now started a clinical trial on patients.

In glaucoma, the optic nerve is gradually damaged, leading to vision loss and, in the worst cases, blindness. High pressure in the eye drives the disease, and eye drops, laser treatment or surgery are therefore used to…

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News Source: www.sciencedaily.com

May 8, 2025
Incidence of several early-onset cancers increased between 2010 and 2019

In the United States, breast, colorectal, endometrial, pancreatic, and kidney cancers are becoming increasingly common among people under age 50, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research (AACR).

The findings may have implications for early-onset cancer prevention and screening efforts, the researchers noted.

Early-onset cancers, defined in this study as those diagnosed in individuals under age 50, are rising in incidence…

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News Source: www.sciencedaily.com

May 8, 2025
AI-designed DNA controls genes in healthy mammalian cells for first time

A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. Researchers at the Centre for Genomic Regulation (CRG) created an AI tool which dreams up DNA regulatory sequences not seen before in nature. The model can be told to create synthetic fragments of DNA with custom criteria, for example: ‘switch this gene on in stem cells which will turn into…

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News Source: www.sciencedaily.com

May 8, 2025
$1.8 billion in NIH grant cuts hit minority health research the hardest

The headlines keep coming: Another federal grant funding medical research terminated. Another lab devoted to mental health losing its funding. Another clinical trial stopped.

It’s all part of actions the Trump administration says are needed to make government more efficient or to eliminate funding related to diversity, equity and inclusion. Opponents say the cuts undermine crucial medical research, gut careers and damage U.S. leadership in science.

“When policies shift…

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News Source: www.sciencenews.org

May 8, 2025
Why is Trump going to the Middle East? | Donald Trump

Trump aims to drum up financial support for the US with his Middle East trip, but Iran and Gaza also hang in the balance.

United States President Donald Trump plans to tout trillions of dollars of Arab investments in the US as a major achievement, but other issues are at stake, says University of Maryland professor Shibley Telhami.

Israel is threatening to further destroy the Gaza Strip unless progress is made in its ceasefire talks with Hamas. Meanwhile, Israel has refused to allow any food…

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News Source: www.aljazeera.com

May 8, 2025
Trump ‘Disappointed’ with Netanyahu, Excludes Israel from Regional Plans – Report

Israeli PM Benjamin Netanyahu and US President Donald Trump. (Design: Palestine Chronicle)

By Palestine Chronicle Staff

Tensions escalate between Trump and Netanyahu as the former president moves forward with Middle East plans—excluding Israel—amid the ongoing Israeli blockade on Gaza.

Tensions between former US President Donald Trump and Israeli Prime Minister Benjamin Netanyahu appear to be escalating, according to the Israeli newspaper Israel Hayom.

Citing sources with…

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News Source: www.palestinechronicle.com

May 8, 2025
US-UK trade deal: How are Trump’s global tariff talks shaping up? | International Trade News

United States President Donald Trump is expected to announce the framework of a trade deal between the US and the United Kingdom on Thursday, according to people familiar with the plan.

On Wednesday, Trump said he was preparing to announce “a major trade deal with representatives of a big and highly respected country”. In a post on Truth Social, he promised it would be the “first of many”.

Investors have been waiting for Trump to ease his global trade war amid fears that prolonged…

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News Source: www.aljazeera.com

May 8, 2025
New Shireen Abu Akleh documentary ‘identifies her killer’

The makers of new documentary ‘Who Killed Shireen?’ say they have identified the Israeli soldier who shot her.

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News Source: www.aljazeera.com

May 8, 2025