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  • New study challenges assumptions about SEP-1 bundle compliance and sepsis outcomes

    New study challenges assumptions about SEP-1 bundle compliance and sepsis outcomes

    A new study led by the Center for Sepsis Epidemiology and Prevention Studies (SEPSIS) at the Harvard Pilgrim Health Care Institute raises critical questions about the effectiveness of the Centers for Medicare and Medicaid Services’ (CMS) sepsis quality measure, known as the Severe Sepsis/Septic Shock Management Bundle (SEP-1).

    Sepsis, a life-threatening condition arising from dysregulated physiological response to infection, requires rapid treatment to improve survival. In 2015, CMS…

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    News Source: www.sciencedaily.com

  • Pregnancy irreversibly remodels the mouse intestine

    Pregnancy irreversibly remodels the mouse intestine

    Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare for a second.

    The organs of many female animals are remodelled by reproduction, but the underlying mechanisms behind the response of the gut to pregnancy have only recently begun to be investigated. For example, scientists previously identified that the fruit fly gut expands during…

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    News Source: www.sciencedaily.com

  • Rethinking how we study the impact of heat on heart health

    Rethinking how we study the impact of heat on heart health

    Scientists have been testing how heat affects our hearts for years. But here’s the thing: the most commonly used method might not provide much insight into what happens to the heart during heat waves.

    A new study led by the University of Ottawa, Human and Environmental Physiology Research Unit with researchers from Harvard University, University of Otago, Institute for Exercise and Environmental Medicine, and the University of Portsmouth, has revealed critical insights into how we test…

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    News Source: www.sciencedaily.com

  • Machine learning aids in detection of ‘brain tsunamis’

    Machine learning aids in detection of ‘brain tsunamis’

    A University of Cincinnati study found machine learning models can aid in the automation and detection of abnormal brain activity sometimes referred to as a “brain tsunami.”

    UC’s Jed Hartings, PhD, is corresponding author of the study published March 12 in the journal Scientific Reports detailing how automation can aid clinicians treating patients with spreading depolarizations (SDs).

    What is a spreading depolarization?

    Hartings said SDs are believed to occur in patients with virtually any…

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    News Source: www.sciencedaily.com

  • Earliest stages and possible new cause of stomach cancer revealed

    Earliest stages and possible new cause of stomach cancer revealed

    For the first time, scientists have systematically analysed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer. The team also uncovered hints of a potential new cause of stomach cancer that needs further research.

    Researchers at the Wellcome Sanger Institute, Broad Institute of MIT and Harvard, the University of Hong Kong, and their collaborators sequenced the whole genomes of normal stomach lining samples from people with and without…

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    News Source: www.sciencedaily.com

  • Why are night owls at greater risk of depression?

    Why are night owls at greater risk of depression?

    Mindfulness, total sleep quality, and alcohol consumption may help explain why people who stay up late have a greater risk of depression, according to a new study publishing March 19, 2025, in the open-access journal PLOS One by Simon Evans of University of Surrey, UK, and colleagues.

    Previous research has shown that night owls who stay up late, called “evening chronotypes,” have more depression symptoms than people who are early risers, or “morning chronotypes.” In the new study, Evans and…

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    News Source: www.sciencedaily.com

  • New mechanism behind adaptive immunity revealed: It could impact how we design vaccines

    New mechanism behind adaptive immunity revealed: It could impact how we design vaccines

    Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check. But rapid evolution should come at a cost. Most mutations are deleterious, so constant mutation during every cell division, coupled with unchecked proliferation, should be a recipe for disaster. How B cells somehow rapidly mutate and improve all at once was…

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    News Source: www.sciencedaily.com

  • New understanding of B cell mutation strategies could have implications for vaccines

    New understanding of B cell mutation strategies could have implications for vaccines

    A vaccine’s ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies. But each round of this process is a roll of the genetic dice—every mutation has the potential to improve affinity; far more often, however, it degrades or destroys a functional antibody. How do high-affinity B cells ever beat the odds?

    New…

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    News Source: www.sciencedaily.com

  • Classifying childhood brain cancers by immune response may improve diagnostics and treatments

    Classifying childhood brain cancers by immune response may improve diagnostics and treatments

    Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh developed a new way to profile brain cancers in children, paving the way for improved diagnostics and treatments.

    Today in Science Translational Medicine, researchers describe a diagnostic platform that could classify brain tumors based on the body’s cancer-fighting immune response. This approach, which is complementary to traditional microscopic and genetic…

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    News Source: www.sciencedaily.com

  • A child in Gaza watched his mother burn alive. Then he died too. – Mondoweiss

    A child in Gaza watched his mother burn alive. Then he died too. – Mondoweiss

    On Tuesday night, in the Qarara area east of Khan Younis in southern Gaza, brothers Muhammad and Ibrahim Hamidi decided to take their children and flee to a less dangerous location east of the city. The sound of heavy gunfire from tanks stationed near their home after a brutal night of nonstop shelling and bombardment pushed them to head toward the Mawasi area of Khan Younis, the same coastal stretch of land that had served as a so-called “safe zone” throughout the war.

    The…

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    News Source: mondoweiss.net