Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check. But rapid evolution should come at a cost. Most mutations are deleterious, so constant mutation during every cell division, coupled with unchecked proliferation, should be a recipe for disaster. How B cells somehow rapidly mutate and improve all at once was…
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News Source: www.sciencedaily.com
