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  • Researchers identify growing list of genetic disorders treatable before or immediately after birth

    Researchers identify growing list of genetic disorders treatable before or immediately after birth

    Researchers from Mass General Brigham, Harvard Medical School and Duke University School of Medicine have identified nearly 300 genetic disorders that can be treated before or immediately after a baby is born. This “treatable fetal findings list” could improve the diagnosis of genetic conditions in pregnancy and enhance the treatment options available for fetuses who have these conditions. Findings are published in the American Journal of Human Genetics.

    “We saw a critical gap in prenatal…

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    News Source: www.sciencedaily.com

  • Osteoarthritis: Largest genome-wide association study uncovers drug targets and therapy opportunities

    Osteoarthritis: Largest genome-wide association study uncovers drug targets and therapy opportunities

    Osteoarthritis is the leading cause of disability and chronic pain worldwide, affecting an estimated 595 million people globally. Projections suggest that this number will rise to 1 billion by 2050. Despite its profound impact on individuals and societies, no disease-modifying treatments are currently available. Now, an international team of researchers led by Helmholtz Munich has made new discoveries by studying the genetics of osteoarthritis in nearly 2 million individuals, uncovering…

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    News Source: www.sciencedaily.com

  • A comprehensive map of the human cell

    A comprehensive map of the human cell

    Scientists have attempted to map the human cell since the first microscope was invented more than 400 years ago. But many components of the cell still remain uncharted.

    “We know each of the proteins that exist in our cells, but how they fit together to then carry out the function of a cell still remains largely unknown across cell types,” said Leah Schaffer, Ph.D., a postdoctoral research scholar at UC San Diego School of Medicine.

    Now, Schaffer and her colleagues at UC San Diego — in…

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    News Source: www.sciencedaily.com

  • Your skin is breathing: New wearable device can measure it

    Your skin is breathing: New wearable device can measure it

    Northwestern University researchers have developed the first wearable device for measuring gases emitted from and absorbed by the skin.

    By analyzing these gases, the device offers an entirely new way to assess skin health, including monitoring wounds, detecting skin infections, tracking hydration levels, quantifying exposure to harmful environmental chemicals and more.

    The new technology comprises a collection of sensors that precisely measure changes in temperature, water vapor, carbon…

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    News Source: www.sciencedaily.com

  • New gene editing tool shows promise for treating diseases with multiple mutations

    New gene editing tool shows promise for treating diseases with multiple mutations

    Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations. The system can be formulated completely as RNA, dramatically simplifying delivery logistics compared to traditional systems that use both RNA and DNA. By inserting an entire gene, the tool offers a one-and-done approach that overcomes hurdles from CRISPR gene editing…

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    News Source: www.sciencedaily.com

  • Potential Alzheimer’s disease therapeutic target identified in brain immune cells

    Potential Alzheimer’s disease therapeutic target identified in brain immune cells

    Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in Nature, researchers from Mass General Brigham used preclinical models to uncover Tim-3’s role in microglia, the brain’s resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.

    “Immune checkpoint inhibitors have revolutionized cancer…

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    News Source: www.sciencedaily.com

  • ‘Sugar’ signatures help identify and classify pancreatic cancer cell subtypes

    ‘Sugar’ signatures help identify and classify pancreatic cancer cell subtypes

    Van Andel Institute scientists and collaborators have developed a new method for identifying and classifying pancreatic cancer cell subtypes based on sugars found on the outside of cancer cells.

    These sugars, called glycans, help cells recognize and communicate with each other. They also act as a cellular “signature,” with each subtype of pancreatic cancer cell possessing a different composition of glycans.

    The new method, multiplexed glycan immunofluorescence, combines specialized software…

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    News Source: www.sciencedaily.com

  • Engineering smart delivery for gene editors

    Engineering smart delivery for gene editors

    Modern genome editing techniques, including CRISPR systems, hold great potential for treating genetic diseases. However, delivering these molecular tools reliably to their target cells remains a significant challenge.

    “Previous viral and non-viral delivery systems such as adeno-associated viruses (AAVs), lipid nanoparticles (LNPs), and other virus-like particles (VLPs), have been valuable but face limitations,” says Dr. Dong-Jiunn Jeffery Truong, last author of the study and group leader at…

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    News Source: www.sciencedaily.com

  • America’s Dependence On Foreign Medicine Is A Risk We Can’t Afford

    America’s Dependence On Foreign Medicine Is A Risk We Can’t Afford

    Although last week’s extensive tariff announcements exempted pharmaceuticals, President Trump has repeatedly maintained that he will eventually impose tariffs on the industry. The tariffs, touted as a remedy to our global vulnerabilities, have thrust the long-ignored flaws of our drug supply chain into the spotlight.

    While tariffs are not a silver bullet, they are a critical catalyst for overdue change. They force the…

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    News Source: www.forbes.com

  • Israel pushes on with strategy to keep neighbours weak in Lebanon and Syria | Syria’s War News

    Israel pushes on with strategy to keep neighbours weak in Lebanon and Syria | Syria’s War News

    Beirut, Lebanon – Israel’s continuing attacks intend to keep its neighbours unstable, weak and fragmented, analysts say, and are contributing to the derailing of governing projects in Lebanon and Syria.

    Conversations with experts, analysts, and diplomats reveal a belief that Israel wants to keep the two states weak and fractured, maintaining Israel as the strongest regional power.

    “The Israelis believe that having weaker neighbors, as in states that aren’t really able to function, is…

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    News Source: www.aljazeera.com