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  • Scientists complete largest wiring diagram and functional map of the brain to date

    Scientists complete largest wiring diagram and functional map of the brain to date

    From a tiny sample of tissue no larger than a grain of sand, scientists have come within reach of a goal once thought unattainable: building a complete functional wiring diagram of a portion of the brain. In 1979, famed molecular biologist, Francis Crick, stated that it would be “[impossible] to create an exact wiring diagram for a cubic millimeter of brain tissue and the way all its neurons are firing.” But during the last seven years, a global team of more than 150 neuroscientists and…

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    News Source: www.sciencedaily.com

  • long-term effects of obesity on brain and cognitive health

    long-term effects of obesity on brain and cognitive health

    With the global prevalence of obesity on the rise, it is crucial to explore the neural mechanisms linked to obesity and its influence on brain and cognitive health. However, the impact of obesity on the brain is complex and multilevel. To address this, Prof. Anqi QIU, Professor of the Department of Health Technology and Informatics at the Hong Kong Polytechnic University (PolyU) and Global STEM Scholar, has unveiled novel research to advance our understanding of the neural mechanisms…

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    News Source: www.sciencedaily.com

  • Treatment for mitochondrial diseases within reach

    Treatment for mitochondrial diseases within reach

    A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production. Researchers at the University of Gothenburg have identified a molecule that helps more mitochondria function properly.

    Mitochondrial diseases caused by POLG mutations vary in severity. In young children, these diseases can quickly result in brain damage and life-threatening liver problems while others suffer muscle weakness, epilepsy, and organ…

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    News Source: www.sciencedaily.com

  • By re-creating neural pathway in dish, Stanford Medicine research may speed pain treatment

    By re-creating neural pathway in dish, Stanford Medicine research may speed pain treatment

    Stanford Medicine investigators have replicated, in a lab dish, one of humans’ most prominent nervous pathways for sensing pain. This nerve circuit transmits sensations from the body’s skin to the brain. Once further processed in the brain, these signals will translate into our subjective experience, including the uncomfortable feeling of pain.

    The advance promises to accelerate what has been slow progress in understanding how pain signals are processed in humans and how best to alleviate…

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    News Source: www.sciencedaily.com

  • Researchers identify growing list of genetic disorders treatable before or immediately after birth

    Researchers identify growing list of genetic disorders treatable before or immediately after birth

    Researchers from Mass General Brigham, Harvard Medical School and Duke University School of Medicine have identified nearly 300 genetic disorders that can be treated before or immediately after a baby is born. This “treatable fetal findings list” could improve the diagnosis of genetic conditions in pregnancy and enhance the treatment options available for fetuses who have these conditions. Findings are published in the American Journal of Human Genetics.

    “We saw a critical gap in prenatal…

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    News Source: www.sciencedaily.com

  • Osteoarthritis: Largest genome-wide association study uncovers drug targets and therapy opportunities

    Osteoarthritis: Largest genome-wide association study uncovers drug targets and therapy opportunities

    Osteoarthritis is the leading cause of disability and chronic pain worldwide, affecting an estimated 595 million people globally. Projections suggest that this number will rise to 1 billion by 2050. Despite its profound impact on individuals and societies, no disease-modifying treatments are currently available. Now, an international team of researchers led by Helmholtz Munich has made new discoveries by studying the genetics of osteoarthritis in nearly 2 million individuals, uncovering…

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    News Source: www.sciencedaily.com

  • A comprehensive map of the human cell

    A comprehensive map of the human cell

    Scientists have attempted to map the human cell since the first microscope was invented more than 400 years ago. But many components of the cell still remain uncharted.

    “We know each of the proteins that exist in our cells, but how they fit together to then carry out the function of a cell still remains largely unknown across cell types,” said Leah Schaffer, Ph.D., a postdoctoral research scholar at UC San Diego School of Medicine.

    Now, Schaffer and her colleagues at UC San Diego — in…

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    News Source: www.sciencedaily.com

  • Your skin is breathing: New wearable device can measure it

    Your skin is breathing: New wearable device can measure it

    Northwestern University researchers have developed the first wearable device for measuring gases emitted from and absorbed by the skin.

    By analyzing these gases, the device offers an entirely new way to assess skin health, including monitoring wounds, detecting skin infections, tracking hydration levels, quantifying exposure to harmful environmental chemicals and more.

    The new technology comprises a collection of sensors that precisely measure changes in temperature, water vapor, carbon…

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    News Source: www.sciencedaily.com

  • New gene editing tool shows promise for treating diseases with multiple mutations

    New gene editing tool shows promise for treating diseases with multiple mutations

    Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations. The system can be formulated completely as RNA, dramatically simplifying delivery logistics compared to traditional systems that use both RNA and DNA. By inserting an entire gene, the tool offers a one-and-done approach that overcomes hurdles from CRISPR gene editing…

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    News Source: www.sciencedaily.com

  • Potential Alzheimer’s disease therapeutic target identified in brain immune cells

    Potential Alzheimer’s disease therapeutic target identified in brain immune cells

    Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in Nature, researchers from Mass General Brigham used preclinical models to uncover Tim-3’s role in microglia, the brain’s resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.

    “Immune checkpoint inhibitors have revolutionized cancer…

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    News Source: www.sciencedaily.com