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  • Brain study increases understanding of what triggers drug use relapse

    Brain study increases understanding of what triggers drug use relapse

    New research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and thereby the formation of strong drug-related memories, which can trigger relapse in individuals with substance use disorders (SUDs). The study in Biological Psychiatry, published by Elsevier, detailing these epigenetic mechanisms in the brain, uncovers a new molecular target for the development…

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    News Source: www.sciencedaily.com

  • Study provides scaffold to selectively target drug breakdown process

    Study provides scaffold to selectively target drug breakdown process

    Scientists at St. Jude Children’s Research Hospital explored selectively blocking the CYP3A4 protein responsible for breaking down large swaths of approved drugs, providing a way to improve drug efficacy.

    Cytochrome P450 (CYP) proteins are responsible for breaking down more than 80% of all Food and Drug Administration (FDA) approved drugs, reducing their effectiveness. However, how to prevent CYPs from doing this without off-target effects has puzzled researchers until now. Scientists at St….

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    News Source: www.sciencedaily.com

  • Scientists develop process using molecules in the cell to identify environmental signals

    Scientists develop process using molecules in the cell to identify environmental signals

    Scientists have transformed RNA, a biological molecule present in all living cells, into a biosensor that can detect tiny chemicals relevant to human health.

    Research by Rutgers University-New Brunswick scientists centers on RNA, a nucleic acid that plays a crucial role in most cellular processes. Their work is expected to have applications in the surveillance of environmental chemicals and, ultimately, the diagnosis of critical diseases including neurological and cardiovascular diseases and…

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    News Source: www.sciencedaily.com

  • New phase of the immune response uncovered

    New phase of the immune response uncovered

    The research groups led by Wolfgang Kastenmüller and Georg Gasteiger employed innovative microscopy techniques to observe how specific immune cells, known as T-cells, are activated and proliferate during a viral infection. Their findings revealed novel mechanisms: the immune system amplifies its defense cells in a far more targeted way than previously believed.

    T-Cells Proliferate and Specialize During the Immune Response

    T-cells are crucial defense cells in the immune system. To…

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    News Source: www.sciencedaily.com

  • Brain pathway links inflammation to loss of motivation, energy in advanced cancer

    Brain pathway links inflammation to loss of motivation, energy in advanced cancer

    The fatigue and lack of motivation that many cancer patients experience near the end of life have been seen as the unavoidable consequences of their declining physical health and extreme weight loss. But new research from Washington University School of Medicine in St. Louis challenges that long-held assumption, showing instead that these behavioral changes stem from specific inflammation-sensing neurons in the brain.

    In a study published April 11 in Science, the researchers report that they…

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    News Source: www.sciencedaily.com

  • Researchers put glycemic response modeling on a data diet

    Researchers put glycemic response modeling on a data diet

    If you eat a snack — a meatball, say, or a marshmallow — how will it affect your blood sugar? It’s a surprisingly tricky question: the body’s glycemic response to different foods varies based on individual genetics, microbiomes, hormonal fluctuations, and more. Because of that, providing personalized nutritional advice — which can help manage diabetes, obesity, and cardiovascular diseases, among other conditions — requires costly and intrusive testing, making it hard to deliver effective…

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    News Source: www.sciencedaily.com

  • Genes in bacterial genomes are arranged in a meaningful order

    Genes in bacterial genomes are arranged in a meaningful order

    Bioinformaticians from Heinrich Heine University Düsseldorf (HHU) and the university in Linköping (Sweden) have established that the genes in bacterial genomes are arranged in a meaningful order. In the journal Science, they describe that the genes are arranged by function: If they become increasingly important at faster growth, they are located near the origin of DNA replication. Accordingly, their position influences how their activity changes with the growth rate.

    Are genes distributed…

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    News Source: www.sciencedaily.com

  • American Airlines planes bump wings at Washington airport | Aviation News

    American Airlines planes bump wings at Washington airport | Aviation News

    An American Airlines plane carrying at least three members of the United States Congress has been struck on the taxiway by the wingtip of another American Airlines jet at Ronald Reagan Washington National Airport, the Federal Aviation Administration (FAA) says.

    American Airlines Flight 5490, a Bombardier CRJ 900 headed to Charleston, South Carolina, struck American Flight 4522, an Embraer E175 headed to New York’s John F Kennedy International Airport, about 12:45pm (16:45 GMT) on Thursday,…

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    News Source: www.aljazeera.com

  • Iran, US raise stakes ahead of key talks in Oman

    Iran, US raise stakes ahead of key talks in Oman

    Washington and Tehran waged a war of words Thursday ahead of key talks in Oman after US President Donald Trump said military action was “absolutely” possible if the talks fail.

    A senior adviser to supreme leader Ayatollah Ali Khamenei warned that Iran could expel UN nuclear watchdog inspectors over “threats” ahead of Saturday’s talks.

    Rear Admiral Ali Shamkhani’s comments came after US Trump Wednesday failed to rule out military action against Iran in the event the planned talks fail to…

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    News Source: www.al-monitor.com

  • US-Russia prisoner swap: Ukraine aid donor for tech smuggler

    US-Russia prisoner swap: Ukraine aid donor for tech smuggler

    Russia freed US citizen Ksenia Karelina, jailed for donating to Ukraine aid, in swap for accused smuggler Arthur Petrov.

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    News Source: www.aljazeera.com