Category: 4. Health

  • The long pathway to cell organization and growth

    The long pathway to cell organization and growth

    Sterols, such as cholesterol in our bodies or ergosterol in yeast cells, are among the most abundant lipids in eukaryotic cells, yet are synthesized through notoriously long, complex metabolic pathways. Researchers from UC San Diego and the NIH have used a novel combination of cell biology, in vitro biochemistry and molecular computer simulations to show that in yeast, this pathway shapes the ergosterol to balance its interactions with other lipids. This balancing act allows for the…

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    News Source: www.sciencedaily.com

  • Recessive genes are subject to Darwinian selection

    Recessive genes are subject to Darwinian selection

    As a group, carriers of recessive disorders are slightly less healthy and have a reduced chance of having offspring. This disadvantage is greatest for carriers of a recessive gene for intellectual disability, and reflected in a shorter school career and increased childlessness, according to research from Radboudumc. Time to rewrite the textbooks?

    Dominant mutation

    Researchers from Radboudumc, Department of Human Genetics, demonstrated something remarkable in a 2014 publication in Nature….

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    News Source: www.sciencedaily.com

  • Patients with glioblastoma who received gabapentin lived longer, study suggests

    Patients with glioblastoma who received gabapentin lived longer, study suggests

    A new study by investigators from Mass General Brigham suggests that gabapentin, a relatively common anti-seizure/pain medication, is linked to improved survival in patients with glioblastoma (GBM) — the most common and deadly form of brain cancer in adults. The findings, published in Nature Communications, are based on a retrospective analysis and add new evidence to help patients with this devastating disease.

    “This study is an exciting step forward,” said lead author Joshua Bernstock,…

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    News Source: www.sciencedaily.com

  • Cyberbullying in any form can be traumatizing for kids

    Cyberbullying in any form can be traumatizing for kids

    As concern grows over adolescent mental health, a new national study adds to the growing body of research showing that cyberbullying should be considered an adverse childhood experience (ACE) — a category of childhood trauma linked to long-term emotional, psychological and physical harm.

    While many assume that only extreme forms of online harassment — like threats or identity-based attacks — can cause significant harm, the findings suggest a more troubling reality: even less visible or…

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    News Source: www.sciencedaily.com

  • Focused ultrasound halts growth of debilitating brain lesions

    Focused ultrasound halts growth of debilitating brain lesions

    A new, incision-free technique developed at UVA Health to treat debilitating brain lesions called cerebral cavernous malformations, or cavernomas, has shown great promise in early testing, halting the growth of the lesions almost entirely.

    The new approach could represent a paradigm shift in how the malformations, commonly called CCMs, are treated, the researchers say. The technique uses tiny, gas-filled “microbubbles” propelled by focused sound waves to open the brain’s protective barrier…

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    News Source: www.sciencedaily.com

  • South African study identifies two new breast cancer genes in black women

    South African study identifies two new breast cancer genes in black women

    Genetic factors contribute to some 30% of breast cancer cases in SA, necessitating investment in genomic research in African contexts.

    A seminal genetic study published in Nature Communication has discovered two genetic variants linked to breast cancer in black South African women, deepening knowledge about the genetic basis for this disease in African populations.

    The genome-wide association study (GWAS) of breast cancer is the first to have been done in African women living on the…

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    News Source: www.sciencedaily.com

  • Shorter radiation therapy after prostate surgery safe, study finds

    Shorter radiation therapy after prostate surgery safe, study finds

    For men who undergo a radical prostatectomy for the treatment of prostate cancer, post-surgery radiation therapy can play a vital role in reducing the risk of recurrence. Despite its benefits, many patients decline or defer radiation because it requires daily sessions for several weeks.

    Now, a new study published in JAMA Oncology and led by UCLA Health Jonsson Comprehensive Cancer Center investigators suggests there may be a faster option. Researchers found that stereotactic body…

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    News Source: www.sciencedaily.com

  • Improved model system allows researchers to study embryo development

    Improved model system allows researchers to study embryo development

    Research from Ph.D. candidate Bohan Chen in the lab of Idse Heemskerk of the Department of Cell and Developmental Biology at the University of Michigan Medical School and their colleagues improves upon a popular experimental model and in doing so, reveals more of the inner workings of a critical period during the formation of an embryo.

    Scientists study development in part to understand what can go wrong as the body’s structures are formed.

    The ultimate hope is to be able to prevent birth…

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    News Source: www.sciencedaily.com

  • New stem cell model sheds light on human amniotic sac development

    New stem cell model sheds light on human amniotic sac development

    Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four weeks after fertilisation. This is the first model of amniotic sac development after two weeks.

    As described in research published today in Cell, the new model can be used to study the origin and function of the human amnion and help identify previously unknown ways the amniotic sac might support…

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    News Source: www.sciencedaily.com

  • How rearranged genes drive kidney cancer progression

    How rearranged genes drive kidney cancer progression

    In findings from a study led by investigators at the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins Bloomberg School of Public Health, scientists report that they have learned how certain combinations of rearranged genes can promote the progression of a rare type of kidney cancer. The work was supported by the National Institutes of Health.

    The researchers demonstrated that proteins made from these rearranged, so-called fusion genes form tiny liquid droplets inside the cell, where…

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    News Source: www.sciencedaily.com