Category: 4. Health

  • DNA origami guides new possibilities in the fight against pancreatic cancer

    DNA origami guides new possibilities in the fight against pancreatic cancer

    One of the challenges of fighting pancreatic cancer is finding ways to penetrate the organ’s dense tissue to define the margins between malignant and normal tissue. A new study uses DNA origami structures to selectively deliver fluorescent imaging agents to pancreatic cancer cells without affecting normal cells.

    The study, led by University of Illinois Urbana-Champaign mechanical science and engineering professor Bumsoo Han and professor Jong Hyun Choi at Purdue University, found that…

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    News Source: www.sciencedaily.com

  • Behavioral Health Is Breaking The Bank — Here’s How To Invest Wisely

    Behavioral Health Is Breaking The Bank — Here’s How To Invest Wisely

    Behavioral health has become a front-and-center concern for families, employers and wealth advisors alike. It’s now a boardroom conversation, a family dinner topic, and a growing risk factor for high-net-worth families. Left unmanaged, these issues can disrupt family dynamics, derail careers, deplete wealth and complicate legacy planning. But while awareness has surged, navigating treatment remains challenging,…

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    News Source: www.forbes.com

  • ‘One Of The Most Complex Diseases In Medicine:’ What We Still Don’t Know About Parkinson’s Disease

    ‘One Of The Most Complex Diseases In Medicine:’ What We Still Don’t Know About Parkinson’s Disease

    While many of us have become more enlightened during this Parkinson’s Awareness Month, about a million people in the United States have been working to manage the disease in their day-to-day lives. In fact, Parkinson’s disease is the second-most common neurodegenerative disease after Alzheimer’s, according to the Parkinson’s Foundation.

    While many of the nearly 100,000 people diagnosed with…

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    News Source: www.forbes.com

  • Researchers use machine learning to engineer ‘bespoke enzymes’ for gene editing

    Researchers use machine learning to engineer ‘bespoke enzymes’ for gene editing

    Genome editing has advanced at a rapid pace with promising results for treating genetic conditions — but there is always room for improvement. A new paper by investigators from Mass General Brigham published in Nature showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm — known as PAMmla — that can predict the properties of about 64 million…

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    News Source: www.sciencedaily.com

  • New technique expands tissues so hundreds of biomolecules can be seen inside cells

    New technique expands tissues so hundreds of biomolecules can be seen inside cells

    For biologists, seeing is believing. But sometimes biologists have a hard time seeing.

    One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of single cells, simultaneously. Detecting the location of hundreds or thousands of biomolecules — from lipids to metabolites to proteins — in their native environment allows researchers to better understand their functions and interactions. Unfortunately, scientists don’t have great tools to…

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    News Source: www.sciencedaily.com

  • A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain

    A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain

    A preclinical study from scientists at Scripps Research finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity — two issues that commonly co-occur with alcohol use disorder (AUD).

    The results, published in JCI Insight on April 22, 2025, suggest that the drug apremilast — a phosphodiesterase-4 (PDE4) inhibitor, or a compound that blocks an enzyme involved in inflammation — could be repurposed as a dual-acting…

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    News Source: www.sciencedaily.com

  • The most effective prevention method for complications post lung transplant

    The most effective prevention method for complications post lung transplant

    When receiving a lung transplant, one of the most important complications to look out for is chronic lung allograft dysfunction, known as CLAD.

    Preventing this complication for those who receive a lung transplant is of the highest priority, as there are no universally effective treatments for CLAD once it is established.

    The most common of the immunosuppressing medications given to lung transplant recipients are calcineurin inhibitors.

    Only two calcineurin inhibitors exist, cyclosporine and…

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    News Source: www.sciencedaily.com

  • Obesity disrupts ‘reaction time’ to starvation in mice

    Obesity disrupts ‘reaction time’ to starvation in mice

    Researchers led by Keigo Morita and Shinya Kuroda of the University of Tokyo have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network. This is a breakthrough discovery as research including the temporal dimension in biology has been notoriously laborious and extracting systematic insight from big data has been difficult. Thus, this study paves the way for further research into more…

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    News Source: www.sciencedaily.com

  • Boosting Bispecific Antibody Yields with >98% Purity

    Boosting Bispecific Antibody Yields with >98% Purity

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    Bispecific antibodies (bsAbs) are shaping the future of therapeutics, but challenges like limited throughput, low yields, and chain mispairing across diverse formats can slow progress.

    This white paper shares practical strategies and real-world case studies to help you tackle these hurdles. Discover how…

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    News Source: www.labroots.com

  • Empowering antibodies to better activate the immune system

    Empowering antibodies to better activate the immune system

    Antibodies are best known for their ability to latch onto and neutralize bacteria, viruses and other pathogens. But these immune proteins can do more than that: They also activate other components of the immune system, which then go to work to clear an infection. A new study from Scripps Research explores the factors that influence how effectively antibodies engage specific immune cells.

    Their results, described April 22, 2025 in Cell Reports, indicate that a higher ratio of antibodies to…

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    News Source: www.sciencedaily.com