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In the realm of memories, “where” holds special importance. Where did I leave my keys? Where did I eat dinner last night? Where did I first meet that friend? Recalling locations is necessary for daily life, yet spatial memory — which keeps track of “where” — is one of the first cognitive abilities to fade in old age. And deficits earlier in life can be a telltale sign of dementia.
Now, researchers at Stanford Medicine and their colleagues are uncovering what goes awry in older brains when…
News Source: www.sciencedaily.com

The open question is whether policies should lean more heavily on markets, with their proven record of innovation and efficiency, or on government interventions that expand access but risk slowing progress.
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Calls to lower drug prices are back in the headlines, most recently with the president’s TrumpRx initiative aimed at easing the financial burden on patients and taxpayers by bringing U.S. drug prices closer to those paid abroad. The appeal is obvious: cheaper prescriptions today…
News Source: www.forbes.com

Ultra-processed foods (UPFs) have become public enemy number one in nutrition debates. From dementia to obesity and an epidemic of “food addiction,” these factory-made products, including crisps, ready meals, fizzy drinks and packaged snacks, are blamed for a wide range of modern health problems. Some experts argue that they’re “specifically formulated and aggressively marketed to maximise consumption and corporate profits,” hijacking our brain’s reward systems to make us eat beyond our…
News Source: www.sciencedaily.com

Vascular dementia — cognitive impairment caused by disease in the brain’s small blood vessels — is a widespread problem, but it has not been as thoroughly studied as Alzheimer’s disease, in which abnormal plaques and protein tangles are deposited in neural tissue.
One researcher at The University of New Mexico hopes to change that.
In a newly published paper featured by the editors of the American Journal of Pathology, Elaine Bearer, MD, PhD, the Harvey Family Endowed and Distinguished…
News Source: www.sciencedaily.com

News Source: www.sciencedaily.com

The cumulative effect of social advantages across a lifetime – from parental warmth in childhood to friendship, community engagement and religious support in adulthood – may slow the biological processes of aging. These social advantages appear to set back “epigenetic clocks” such that a person’s biological age, as measured by analyzing DNA methylation patterns, is younger than their chronological age.
The research, which appeared in the October issue of the journal Brain, Behavior and…
News Source: www.sciencedaily.com

Cancer cells mount an instant, energy-rich response to being physically squeezed, according to a study published in the journal Nature Communications. The surge of energy is the first reported instance of a defensive mechanism which helps the cells repair DNA damage and survive the crowded environments of the human body.
The findings help explain how cancer cells survive complex mechanical gauntlets like crawling through a tumor microenvironment, sliding into porous blood vessels or enduring…
News Source: www.sciencedaily.com

Researchers at Leipzig University and Charité – Universitätsmedizin Berlin have discovered a key mechanism for appetite and weight control. It helps the brain to regulate feelings of hunger. In a study, scientists from Collaborative Research Centre (CRC) 1423 – Structural Dynamics of GPCR Activation and Signaling – found how a protein called MRAP2 (melanocortin 2 receptor accessory protein 2) influences the function of the brain receptor MC4R (melanocortin-4 receptor), which plays a…
News Source: www.sciencedaily.com

Drinking any amount of alcohol likely increases the risk of dementia, suggests the largest combined observational and genetic study to date, published online in BMJ Evidence Based Medicine.
Even light drinking — generally thought to be protective, based on observational studies — is unlikely to lower the risk, which rises in tandem with the quantity of alcohol consumed, the research indicates.
Current thinking suggests that there might be an ‘optimal dose’ of alcohol for brain health, but…
News Source: www.sciencedaily.com