Palestine

Category: 4. Health

  • Researchers use machine learning to engineer ‘bespoke enzymes’ for gene editing

    Researchers use machine learning to engineer ‘bespoke enzymes’ for gene editing

    Genome editing has advanced at a rapid pace with promising results for treating genetic conditions — but there is always room for improvement. A new paper by investigators from Mass General Brigham published in Nature showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm — known as PAMmla — that can predict the properties of about 64 million…

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    News Source: www.sciencedaily.com

  • New technique expands tissues so hundreds of biomolecules can be seen inside cells

    New technique expands tissues so hundreds of biomolecules can be seen inside cells

    For biologists, seeing is believing. But sometimes biologists have a hard time seeing.

    One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of single cells, simultaneously. Detecting the location of hundreds or thousands of biomolecules — from lipids to metabolites to proteins — in their native environment allows researchers to better understand their functions and interactions. Unfortunately, scientists don’t have great tools to…

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    News Source: www.sciencedaily.com

  • A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain

    A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain

    A preclinical study from scientists at Scripps Research finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity — two issues that commonly co-occur with alcohol use disorder (AUD).

    The results, published in JCI Insight on April 22, 2025, suggest that the drug apremilast — a phosphodiesterase-4 (PDE4) inhibitor, or a compound that blocks an enzyme involved in inflammation — could be repurposed as a dual-acting…

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    News Source: www.sciencedaily.com

  • The most effective prevention method for complications post lung transplant

    The most effective prevention method for complications post lung transplant

    When receiving a lung transplant, one of the most important complications to look out for is chronic lung allograft dysfunction, known as CLAD.

    Preventing this complication for those who receive a lung transplant is of the highest priority, as there are no universally effective treatments for CLAD once it is established.

    The most common of the immunosuppressing medications given to lung transplant recipients are calcineurin inhibitors.

    Only two calcineurin inhibitors exist, cyclosporine and…

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    News Source: www.sciencedaily.com

  • Obesity disrupts ‘reaction time’ to starvation in mice

    Obesity disrupts ‘reaction time’ to starvation in mice

    Researchers led by Keigo Morita and Shinya Kuroda of the University of Tokyo have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network. This is a breakthrough discovery as research including the temporal dimension in biology has been notoriously laborious and extracting systematic insight from big data has been difficult. Thus, this study paves the way for further research into more…

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    News Source: www.sciencedaily.com

  • Boosting Bispecific Antibody Yields with >98% Purity

    Boosting Bispecific Antibody Yields with >98% Purity

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    Bispecific antibodies (bsAbs) are shaping the future of therapeutics, but challenges like limited throughput, low yields, and chain mispairing across diverse formats can slow progress.

    This white paper shares practical strategies and real-world case studies to help you tackle these hurdles. Discover how…

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    News Source: www.labroots.com

  • Empowering antibodies to better activate the immune system

    Empowering antibodies to better activate the immune system

    Antibodies are best known for their ability to latch onto and neutralize bacteria, viruses and other pathogens. But these immune proteins can do more than that: They also activate other components of the immune system, which then go to work to clear an infection. A new study from Scripps Research explores the factors that influence how effectively antibodies engage specific immune cells.

    Their results, described April 22, 2025 in Cell Reports, indicate that a higher ratio of antibodies to…

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    News Source: www.sciencedaily.com

  • Shining a light on DNA: A rapid, ultra-sensitive, PCR-free detection method

    Shining a light on DNA: A rapid, ultra-sensitive, PCR-free detection method

    PCR genetic analysis has been in the spotlight since COVID-19, but light is now further facilitating PCR-free methods.

    Osaka Metropolitan University scientists have developed a light-induced DNA detection technique, using heterogeneous probe particles, that enables ultra-sensitive and ultra-fast genetic analysis without the need for PCR amplification. This advancement is lighting the way for faster, more affordable, and precise genetic analysis across medicine, environmental science, and…

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    News Source: www.sciencedaily.com

  • Activity stabilizes mixtures | ScienceDaily

    Activity stabilizes mixtures | ScienceDaily

    Asymmetric interactions between molecules may serve as a stabilizing factor for biological systems. A new model from researchers of the department Living Matter Physics at the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) reveals this regulatory role of non-reciprocity. The scientists aim to understand the physical principles based on which particles and molecules are able to form living beings and, eventually, organisms.

    Most organizations, may it be a company, a society…

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    News Source: www.sciencedaily.com

  • Tuning in to blood glucose for simpler early diabetes detection

    Tuning in to blood glucose for simpler early diabetes detection

    The highs and lows of blood glucose aren’t just an energy rollercoaster; they could be a key to detecting diabetes risk early and spare you a needle prick or two.

    Researchers at the University of Tokyo have identified a simple, noninvasive method for assessing blood glucose regulation — an essential factor in diabetes risk. Their approach, based on continuous glucose monitoring (CGM) data, could improve early detection and risk assessment for diabetes without relying on blood samples and…

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    News Source: www.sciencedaily.com