Category: 4. Health

  • Osteoarthritis: Largest genome-wide association study uncovers drug targets and therapy opportunities

    Osteoarthritis: Largest genome-wide association study uncovers drug targets and therapy opportunities

    Osteoarthritis is the leading cause of disability and chronic pain worldwide, affecting an estimated 595 million people globally. Projections suggest that this number will rise to 1 billion by 2050. Despite its profound impact on individuals and societies, no disease-modifying treatments are currently available. Now, an international team of researchers led by Helmholtz Munich has made new discoveries by studying the genetics of osteoarthritis in nearly 2 million individuals, uncovering…

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    News Source: www.sciencedaily.com

  • Potential Alzheimer’s disease therapeutic target identified in brain immune cells

    Potential Alzheimer’s disease therapeutic target identified in brain immune cells

    Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in Nature, researchers from Mass General Brigham used preclinical models to uncover Tim-3’s role in microglia, the brain’s resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.

    “Immune checkpoint inhibitors have revolutionized cancer…

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    News Source: www.sciencedaily.com

  • New gene editing tool shows promise for treating diseases with multiple mutations

    New gene editing tool shows promise for treating diseases with multiple mutations

    Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations. The system can be formulated completely as RNA, dramatically simplifying delivery logistics compared to traditional systems that use both RNA and DNA. By inserting an entire gene, the tool offers a one-and-done approach that overcomes hurdles from CRISPR gene editing…

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    News Source: www.sciencedaily.com

  • Your skin is breathing: New wearable device can measure it

    Your skin is breathing: New wearable device can measure it

    Northwestern University researchers have developed the first wearable device for measuring gases emitted from and absorbed by the skin.

    By analyzing these gases, the device offers an entirely new way to assess skin health, including monitoring wounds, detecting skin infections, tracking hydration levels, quantifying exposure to harmful environmental chemicals and more.

    The new technology comprises a collection of sensors that precisely measure changes in temperature, water vapor, carbon…

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    News Source: www.sciencedaily.com

  • Engineering smart delivery for gene editors

    Engineering smart delivery for gene editors

    Modern genome editing techniques, including CRISPR systems, hold great potential for treating genetic diseases. However, delivering these molecular tools reliably to their target cells remains a significant challenge.

    “Previous viral and non-viral delivery systems such as adeno-associated viruses (AAVs), lipid nanoparticles (LNPs), and other virus-like particles (VLPs), have been valuable but face limitations,” says Dr. Dong-Jiunn Jeffery Truong, last author of the study and group leader at…

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    News Source: www.sciencedaily.com

  • ‘Sugar’ signatures help identify and classify pancreatic cancer cell subtypes

    ‘Sugar’ signatures help identify and classify pancreatic cancer cell subtypes

    Van Andel Institute scientists and collaborators have developed a new method for identifying and classifying pancreatic cancer cell subtypes based on sugars found on the outside of cancer cells.

    These sugars, called glycans, help cells recognize and communicate with each other. They also act as a cellular “signature,” with each subtype of pancreatic cancer cell possessing a different composition of glycans.

    The new method, multiplexed glycan immunofluorescence, combines specialized software…

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    News Source: www.sciencedaily.com

  • America’s Dependence On Foreign Medicine Is A Risk We Can’t Afford

    America’s Dependence On Foreign Medicine Is A Risk We Can’t Afford

    Although last week’s extensive tariff announcements exempted pharmaceuticals, President Trump has repeatedly maintained that he will eventually impose tariffs on the industry. The tariffs, touted as a remedy to our global vulnerabilities, have thrust the long-ignored flaws of our drug supply chain into the spotlight.

    While tariffs are not a silver bullet, they are a critical catalyst for overdue change. They force the…

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    News Source: www.forbes.com

  • At The Brink Of Eradicating HIV, America Retreats From Heroism To Hesitation

    At The Brink Of Eradicating HIV, America Retreats From Heroism To Hesitation

    What an extraordinary moment in medical history: science has handed us the superpower to eradicate HIV/AIDS. Lenacapavir, a once-a-year injection, can treat HIV, prevent transmission, and stop new infections—all with a single shot. This breakthrough opens the door to eliminating HIV from humanity entirely. Yet, instead of seizing this opportunity, the United States retreats from its global leadership role in infectious disease control. In a cruel twist of…

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    News Source: www.forbes.com

  • New AI Model Lets People Speak Using Only Their Thoughts

    New AI Model Lets People Speak Using Only Their Thoughts

    Try to picture being completely conscious and mentally able — but not being able to speak. For people afflicted with paralysis or locked-in syndrome, that is a daily reality. However, a revolutionary brain-to-speech AI software, created by scientists at UC Berkeley and UC San Francisco, is hoping to change that — by…

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    News Source: www.forbes.com

  • Americans die earlier at all wealth levels, even if wealth buys more years of life in the US than in Europe

    Americans die earlier at all wealth levels, even if wealth buys more years of life in the US than in Europe

    Americans at all wealth levels are more likely to die sooner than their European counterparts, with even the richest U.S. citizens living shorter lives than northern and western Europeans. That is the key finding of our new study, published in the New England Journal of Medicine.

    We also found that while the wealthiest Americans live longer than the poorest, the wealth-mortality gap in the U.S. is far more pronounced than in Europe.

    We are a team of health policy researchers who study…

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    News Source: theconversation.com