Category: 4. Health

  • More opportunities to test for Alzheimer’s using new analytical method

    More opportunities to test for Alzheimer’s using new analytical method

    Researchers at Lund University and Washington University have identified a blood marker that reflects the amount of Alzheimer’s pathology in the brain. This discovery may play a key role in determining who is most likely to benefit from the new Alzheimer’s drugs.

    In brief:

    • The blood-based marker (P-tau217) may start to change several years before the onset of Alzheimer’s symptoms. The marker can be measured using a simpler and cheaper analytical method.

    • Compared with a highly…

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    News Source: www.sciencedaily.com

  • Master regulator blocking immunotherapy, paving the way for a new lung cancer treatment

    Master regulator blocking immunotherapy, paving the way for a new lung cancer treatment

    Immune checkpoint inhibitors, a class of immunotherapies that help immune cells attack cancer more effectively, have revolutionized cancer treatment. However, fewer than 20% of patients respond to these treatments, highlighting the urgent need for new strategies tailored to both responders and non-responders.

    KAIST researchers have discovered that ‘DEAD-box helicases 54 (DDX54)’, a type ofRNA-binding protein, is the master regulator that hinders the effectiveness of immunotherapy — opening…

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    News Source: www.sciencedaily.com

  • Finding cancer's 'fingerprints'

    Finding cancer's 'fingerprints'

    Cancer diagnoses traditionally require invasive or labor-intensive procedures such as tissue biopsies. Now, research reveals a method that uses pulsed infrared light to identify molecular profiles in blood plasma that could indicate the presence of certain common cancers. In this proof-of-concept study, blood plasma from more than 2,000 people was analyzed to link molecular patterns to lung cancer, extrapolating a potential ‘cancer fingerprint.’

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    News Source: www.sciencedaily.com

  • Starch-based microplastics could cause health risks in mice

    Starch-based microplastics could cause health risks in mice

    Wear and tear on plastic products releases small to nearly invisible plastic particles, which could impact people’s health when consumed or inhaled. To make these particles biodegradable, researchers created plastics from plant starch instead of petroleum. An initial study published in ACS’ Journal of Agricultural and Food Chemistry shows how animals consuming particles from this alternative material developed health problems such as liver damage and gut microbiome imbalances.

    “Biodegradable…

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    News Source: www.sciencedaily.com

  • long-term effects of obesity on brain and cognitive health

    long-term effects of obesity on brain and cognitive health

    With the global prevalence of obesity on the rise, it is crucial to explore the neural mechanisms linked to obesity and its influence on brain and cognitive health. However, the impact of obesity on the brain is complex and multilevel. To address this, Prof. Anqi QIU, Professor of the Department of Health Technology and Informatics at the Hong Kong Polytechnic University (PolyU) and Global STEM Scholar, has unveiled novel research to advance our understanding of the neural mechanisms…

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    News Source: www.sciencedaily.com

  • Scientists complete largest wiring diagram and functional map of the brain to date

    Scientists complete largest wiring diagram and functional map of the brain to date

    From a tiny sample of tissue no larger than a grain of sand, scientists have come within reach of a goal once thought unattainable: building a complete functional wiring diagram of a portion of the brain. In 1979, famed molecular biologist, Francis Crick, stated that it would be “[impossible] to create an exact wiring diagram for a cubic millimeter of brain tissue and the way all its neurons are firing.” But during the last seven years, a global team of more than 150 neuroscientists and…

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    News Source: www.sciencedaily.com

  • Treatment for mitochondrial diseases within reach

    Treatment for mitochondrial diseases within reach

    A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production. Researchers at the University of Gothenburg have identified a molecule that helps more mitochondria function properly.

    Mitochondrial diseases caused by POLG mutations vary in severity. In young children, these diseases can quickly result in brain damage and life-threatening liver problems while others suffer muscle weakness, epilepsy, and organ…

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    News Source: www.sciencedaily.com

  • By re-creating neural pathway in dish, Stanford Medicine research may speed pain treatment

    By re-creating neural pathway in dish, Stanford Medicine research may speed pain treatment

    Stanford Medicine investigators have replicated, in a lab dish, one of humans’ most prominent nervous pathways for sensing pain. This nerve circuit transmits sensations from the body’s skin to the brain. Once further processed in the brain, these signals will translate into our subjective experience, including the uncomfortable feeling of pain.

    The advance promises to accelerate what has been slow progress in understanding how pain signals are processed in humans and how best to alleviate…

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    News Source: www.sciencedaily.com

  • Osteoarthritis: Largest genome-wide association study uncovers drug targets and therapy opportunities

    Osteoarthritis: Largest genome-wide association study uncovers drug targets and therapy opportunities

    Osteoarthritis is the leading cause of disability and chronic pain worldwide, affecting an estimated 595 million people globally. Projections suggest that this number will rise to 1 billion by 2050. Despite its profound impact on individuals and societies, no disease-modifying treatments are currently available. Now, an international team of researchers led by Helmholtz Munich has made new discoveries by studying the genetics of osteoarthritis in nearly 2 million individuals, uncovering…

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    News Source: www.sciencedaily.com

  • A comprehensive map of the human cell

    A comprehensive map of the human cell

    Scientists have attempted to map the human cell since the first microscope was invented more than 400 years ago. But many components of the cell still remain uncharted.

    “We know each of the proteins that exist in our cells, but how they fit together to then carry out the function of a cell still remains largely unknown across cell types,” said Leah Schaffer, Ph.D., a postdoctoral research scholar at UC San Diego School of Medicine.

    Now, Schaffer and her colleagues at UC San Diego — in…

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    News Source: www.sciencedaily.com