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  • Novel point of attack to combat dangerous tropical diseases

    Novel point of attack to combat dangerous tropical diseases

    Researchers are zeroing in on the Achilles’ heel of pathogens that cause Chagas disease, sleeping sickness and leishmaniasis.

    The efforts of a research team from Bochum and Würzburg give hope for new treatment approaches for dangerous tropical diseases. The researchers have compiled a high-precision inventory of the membrane proteins of cell organelles of the African sleeping sickness pathogen. “Some of these proteins contain components that are specific to parasites and differ…

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    News Source: www.sciencedaily.com

  • Music therapy helps brain-injured children

    Music therapy helps brain-injured children

    Music could provide a breakthrough in assessing consciousness levels in children who have suffered significant brain injuries, according to new research published in the journal Frontiers in Psychology.

    Children with disorders of consciousness rely on those caring for them to provide all aspects of their daily living, including hydration, nutrition, washing and dressing.

    There is currently a lack of tools to assess consciousness in children aged between two and 18 and assessing awareness in…

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    News Source: www.sciencedaily.com

  • Promising Parkinson’s drug decoded | ScienceDaily

    Promising Parkinson’s drug decoded | ScienceDaily

    How well our brain functions depends heavily on the performance of our nerve cells. That is why they are regularly checked for their proper function — defective cell components are marked, disposed of and recycled. This includes the mitochondria, the powerhouses of our cells. Impaired quality control of mitochondria plays a central role in Parkinson’s disease. The research group led by Malte Gersch at the Max Planck Institute for Molecular Physiology in Dortmund (MPI) has now been able to…

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    News Source: www.sciencedaily.com

  • Discovery opens up for new ways to treat chlamydia

    Discovery opens up for new ways to treat chlamydia

    Researchers at Umeå University, Sweden, and Michigan State University, USA, have discovered a type of molecule that can kill chlamydia bacteria but spare bacteria that are important for health. The discovery opens the door for further research towards developing new antibiotics against chlamydia, the world’s most common bacterial sexually transmitted disease with 130 million cases a year.

    “No one should have to live with chlamydia. But the problem is that the treatments we have today do not…

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    News Source: www.sciencedaily.com

  • Evaluating the safety and efficacy of a smallpox vaccine for preventing mpox

    Evaluating the safety and efficacy of a smallpox vaccine for preventing mpox

    The recent global monkeypox (mpox) outbreak, with a new and aggressive variant, has underscored the dire need for safe, broadly effective, and accessible vaccines. The LC16m8 vaccine, an attenuated vaccinia virus strain originally developed for smallpox, is a promising option for countering the mpox virus. Exploring this potential further, researchers employed a cross-species immunological analysis to provide new insights into LC16m8’s immunogenicity and safety against mpox.

    In recent years,…

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    News Source: www.sciencedaily.com

  • Biological age predicts cardiovascular disease morbidity and mortality

    Biological age predicts cardiovascular disease morbidity and mortality

    Looking at your biological age — how old your body really is — can give a clearer picture of your heart disease risk than traditional tools alone. This finding comes from a newly published multicentre study conducted in collaboration between the Universities of Jyväskylä, Tampere, and Helsinki, the Finnish Institute for Health and Welfare (THL), Finland, and the Karolinska Institutet, Sweden.

    Biological ageing refers to the gradual deterioration of cells and tissues in the body that…

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    News Source: www.sciencedaily.com

  • HIV drugs offer ‘substantial’ Alzheimer’s protection, new research indicates

    HIV drugs offer ‘substantial’ Alzheimer’s protection, new research indicates

    UVA Health scientists are calling for clinical trials testing the potential of HIV drugs called NRTIs to prevent Alzheimer’s disease after discovering that patients taking the drugs are substantially less likely to develop the memory-robbing condition.

    The researchers, led by UVA’s Jayakrishna Ambati, MD, previously identified a possible mechanism by which the drugs could prevent Alzheimer’s. That promising finding prompted them to analyze two of the nation’s largest health insurance…

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    News Source: www.sciencedaily.com

  • Reactivity to tumor antigens is important for TIL therapy

    Reactivity to tumor antigens is important for TIL therapy

    A team of researchers from Moffitt Cancer Center has found new insight into why some lung cancer patients do not benefit from tumor-infiltrating lymphocyte, or TIL therapy. Their findings, published in Nature Cancer, may help improve future ways to deliver this cellular immunotherapy for metastatic non-small cell lung cancer.

    TIL therapy is a live cell treatment where a patient’s tumor is surgically removed and sent to a lab where it is dissected to remove the immune cells that have found…

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    News Source: www.sciencedaily.com

  • Engineering an antibody against flu with sticky staying power

    Engineering an antibody against flu with sticky staying power

    Scientists have engineered a monoclonal antibody that can protect mice from a lethal dose of influenza A, a new study shows. The new molecule combines the specificity of a mature flu fighter with the broad binding capacity of a more general immune system defender.

    The protective effect was enhanced by delivering the antibody in a nasal spray that disperses these molecules throughout the respiratory tract, where they stick to the slippery mucus lining to lie in wait for invading viral…

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    News Source: www.sciencedaily.com

  • AI-designed DNA controls genes in healthy mammalian cells for first time

    AI-designed DNA controls genes in healthy mammalian cells for first time

    A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. Researchers at the Centre for Genomic Regulation (CRG) created an AI tool which dreams up DNA regulatory sequences not seen before in nature. The model can be told to create synthetic fragments of DNA with custom criteria, for example: ‘switch this gene on in stem cells which will turn into…

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    News Source: www.sciencedaily.com