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Your cells constantly generate and conduct electricity that runs through your body to perform various functions. One such example of this bioelectricity is the nerve signals that power thoughts in your brain. Others include the cardiac signals that control the beating of your heart, along with other signals that tell your muscles to contract.

As bioengineers, we became interested in the epithelial cells that make up human skin and the outer layer of people’s intestinal tissues. These…

Adeno-associated virus (AAV) is a prominent method for delivering genes in vivo. Therapeutic delivery to target cells is achieved through full capsids containing the gene cargo. However, the presence of empty capsids in the AAV drug product can reduce therapeutic effectiveness, necessitating their detection…

For those who are overweight or obese, medications known as glucagon-like peptide-1 agonists, or GLP-1s, have become very popular as weight loss treatments. Taken in accordance with instructions on the label and an appropriate diet and exercise regimen, GLP-1s are…

In the sixth episode of The Deep End, we’ll look to the future for Jon and his family and for DBS research. The research is pushing ahead, with a clinical trial of DBS for treatment-resistant depression that’s just begun. The first volunteer for that study had DBS surgery in early February. You’ll also hear about a before-and-after situation for Jon and Barbara, one that involves the evolving meaning of a beloved song.

Transcript

Laura Sanders: Previously on The…

In Philadelphia, fatal overdoses are the No. 3 cause of death after heart disease and cancer. That’s been the case each year since 2016, except in 2020 and 2021 when COVID-19 deaths outpaced overdose deaths. The vast majority of fatal overdoses in Philly involve the synthetic opioid fentanyl.

Data on overdose deaths in Philly in 2024 is not yet available. However, new research shows that drug deaths are dropping in all 50 states and the District of Columbia.

Still, opioid overdose…

Since 2022, Colorado and 10 other states have passed voter initiatives to protect or expand abortion access. Yet, seven of these states, including Colorado, require people under the age of 18 to get consent from or notify a parent prior to receiving abortion services.

In January 2025, my colleagues and I published research using in-depth interviews with 33 people ages 15 to 22 in Colorado who considered or obtained abortion care between 2020 and 2023. Our study suggests that…

Anyone who has raised kids knows what happens when you give them a monthly allowance without requiring any work in return: they plop in front of their new videogame consoles while their dirty dishes collect in the sink.

That’s the logic behind Republican plans to establish work requirements for people who receive safety net benefits—if you give them money with no strings attached, they won’t have an incentive to work. By…