The researchers induced the senescent-like state in worms by manipulating the transcription factor TFEB. Under normal conditions, worms subjected to long-term fasting followed by refeeding regenerate and appear rejuvenated. However, in the absence of TFEB, the worm’s stem cells fail to recover from the fasting period and instead enter a senescent-like state. This state is characterised by markers such as DNA damage, nucleolus expansion, mitochondrial reactive oxygen species (ROS), and the…
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News Source: www.sciencedaily.com
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