Ageing promotes metastasis via activation of the integrated stress response

Mice and in vivo studies

Kras^LSL-G12D/+Trp53^flox/flox mice (designated as KP)⁶⁰ were maintained on a mixed C57BL/6-129/Sv genetic background. Lung tumours were induced in young KP (2–3 months old; referred to as KP-Young) and old KP…