Current treatments to prevent organ transplant rejection focus mainly on suppressing T cells, part of the adaptive immune system. However, the innate immune system — the body’s first line of defense that triggers early inflammation after transplantation — has largely remained untargeted by modern therapies.
In a new study, researchers from Mass General Brigham identified a natural “brake” within the innate immune system: the inhibitory receptor Siglec-E (SigE) and its human counterparts,…
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News Source: www.sciencedaily.com
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