Critical role for a high-plasticity cell state in lung cancer

Mice

Previously published genetically engineered mouse strains were used in this study: Kras^LSL-G12D/+ (ref. ¹⁹), Trp53^flox/flox (ref. ⁶²), Kras^FSF-G12D/+ (ref. ²¹), Trp53^frt/frt (ref. ²⁶), Rosa26^mTmG/+ (ref. ³⁶); and Hipp11^FSF-GGCB, Hipp11^FSF-BG,…