PTEN Connection to Autism: Up to 25% of those with brain overgrowth and autistic spectrum disorder (ASD) carry variations in a gene called PTEN; PTEN-deficient mouse models exhibit ASD-like characteristics Cell-type Specific Model: PTEN loss in specific neurons leads to circuit imbalance and altered behavior Excitation-Inhibition Imbalance: Strengthened excitatory drive and loss of local inhibitory connections in an amygdala circuit Behavioral effects: This circuit imbalance results in…
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News Source: www.sciencedaily.com
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