During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner. Many intracellular pathways — series of signalling cascades within a cell — regulate these actions to avoid non-programmed growth that could lead to malformations or cancer. One of these pathways is the PTEN / PI3K axis, a complex series of perfectly balanced chemical reactions.
Mutations in the PTEN gene usually result in the overactivation of PI3K and the imbalance of the…
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News Source: www.sciencedaily.com
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