Maternal Hypertension and Childhood Seizure Risk

A study published in the Journal of Clinical Investigation seeks to understand the relationship between maternal hypertensive disorders of pregnancy (HDP) and the risk of seizures and epilepsy in offspring, leveraging a multi-cohort design that integrates human electronic health records (EHR) across different populations and animal models to elucidate mechanistic pathways.

The initial case-control analysis utilized the IGHK, a dataset from the…