Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis

Mice and in vivo procedures

Kras^LSL−G12D/+; p53^fl/fl (KP) mice have been described previously⁵⁵. KP mice were crossed with Rosa26^{LSL−tdTomato} mice to generate KP; LSL-tdTomato mice. Wild-type C57BL/6 J, Trpv1-cre, Rosa26^LSL−DTR (LSL-DTR),…