It is now possible to obtain three-dimensional, high-resolution images of enzyme activity in tissue samples or whole organs — thanks to probe molecules that anchor fluorescent dyes within tissue as they are activated by enzymes. The organ being mapped is made transparent by a clearing process. As a Japanese team reported in the journal Angewandte Chemie, this allowed for visualization of differences in aminopeptidase N activity and the effects of inhibitors in mouse kidneys.
Enzymes play a…
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News Source: www.sciencedaily.com
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