Decay of driver mutations shapes the landscape of intestinal transformation

Mouse models

The intestinal epithelium-specific Villin-cre^ERT2 (ref. ⁶¹) mouse line was intercrossed with various conditional tumour driver models: Kras^(lsl)G12D/WT (Kras^G12D)⁶², Pik3ca^{(lsl)H1047R/WT} (Pik3ca^H1047R)⁶³, Apc^Δ14/WT (Apc^het)⁶⁴,…