Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology

aSyn expression

Escherichia coli strain BL21(DE3) was transformed with pT7-7 aSyn WT vector⁴³ from Addgene, (plasmid 36046) and plated onto a Luria broth (LB) agar plate containing ampicillin (100 μg ml⁻¹) and 1 g l⁻¹ glucose. A…